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A Journal on Surgery
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Chirurgia 2010 December;23(6):275-8
Colorectal cancer in hiv population
Berretta S., Fisichella R., Didio L., Bertino V., Cimino E., Figura S., D’Agata A., Spartà D.
Unità Operativa Complessa di Clinica Chirurgica II Dipartimento di Chirurgia dell’Università di Catania, P. O. Policlinico
U. O. Chirurgia Generale, AUSL 7, Siena, Italia
The authors report the case of colorectal cancer with liver metastasis in HIV-positive patients. Recent studies have shown a three-fold increased risk of developing non-AIDS cancer in HIV-infected patients when compared to the general population. These patients developed tumours at earlier ages that are diagnosed at an advanced stage. These tumours may be associated with modest immunosuppression (low CD4 cell counts) and perhaps with a tumorigenic effect of the HIV on the colonic epithelium. The impact of highly active antiretroviral therapy needs to be further evaluated and it is also important for these patients the need for assertive prevention strategies (primary and secondary preventions).