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Chirurgia 2010 June;23(3):71-4

Copyright © 2010 EDIZIONI MINERVA MEDICA

language: English

Giant solitary fibrous tumor with cystic area of the anterior mediastinum

Gong L. 1, Li Y-H. 1, Yan X-L. 2, Bai J-J. 3, Liu X-Y. 1, Lu Q. 2, Zhu S-J. 1, Han X-J. 1, Yao L. 1, Zhang W. 1

1 Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, P.R China 2 Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, P.R China 3 Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, P.R China


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Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm originally thought to be restricted to the pleura. It arises in the adult and more commonly in the pleura, but have been reported in other locations, including lung, nasal cavity and mediastinum. We describe a 41-year-old male patient who presented with dyspnea and short breath. Computed tomography (CT) scan revealed the presence of a giant cystic-solid mass (17¥16¥16 cm) in thoracic cavity. During the operation, the mass was found to arise from the anterior mediastinum. Microscopically, the tumor was composed of spindle cells organized in a patternless growth pattern, alternating hyper- and hypo-cellular areas. Mitotic figure was absent. Immuno-histochemically, the tumor cells were positive for vimentin, CD34, CD99 and Bcl-2. Thus, we made the diagnosis of SFT. The long-term follow-up was recommended owing to its large size. Now, the patient is in good health at 5 month’s follow-up. In conclusion, it was extremely rare that a giant SFT with cystic area occurred in anterior mediastinum. The diagnosis was mainly based on histopathological features and immunohistochemical characteristics. The long-term clinical follow-up should be performed because of its potential adverse biologic behavior.

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