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Chirurgia 2009 February;22(1):45-8

language: English

A lung metastasis of large cell neuroendocrine carcinoma of the urinary bladder

Maeda R. 1, Isowa N. 1, Onuma H. 2, Miura H. 2, Koumi T. 3

1 Division of Thoracic Surgery Matsue Red Cross Hospital, Shimane, Japan
2 Division of Pathology Matsue Red Cross Hospital, Shimane, Japan
3 Division of Urology Matsue Red Cross Hospital, Shimane, Japan


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We report a case of a lung metastasis of large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder in a 79-year-old man. The patient underwent radical cystoprostatectomy for a urinary bladder tumor and the postoperative histological diagnosis was LCNEC of the urinary bladder. Six months later, computed tomography scanning of the chest revealed a small nodule in the left lower lobe of the lung, which rapidly increased in size from 0.5 cm to 6 cm over a 10-month period. Positron emission tomography with 18F-fluorodeoxyglucose (FDG-PET) revealed high accumulation at the lesion. We were highly suspicious that the mass was a virulent tumor because it rapidly increased in size and FDG-PET revealed high FDG accumulation. Therefore, we performed a thoracotomy to obtain a definitive diagnosis and for treatment. The postoperative histological diagnosis was lung metastasis of LCNEC of the urinary bladder.

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