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Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1782
Takeuchi K. I., Sakamoto S., Nagayoshi Y., Nishizawa H., Noguchi Y., Kiyosawa J., Matsubara J.
Department of Thoracic and Cardiovascular Surgery Kanazawa Medical University, Ishikawa, Japan
Aim. Serum S-100β protein is an early marker of brain injury following cardiovascular surgery (CVS). In this report, we investigated the changes in serum S-100β protein after CVS.
Methods. 75 cases of CVS with cardiopulmonary bypass (CPB) and 6 cases of CVS without CPB (off-pump coronary artery bypass grafting) were followed between October 2002 and December 2004. S-100β was measured before CVS, directly after weaning from CPB, and at 6, 12 and 24 hours after the end of CPB.
Results. Mean S-100β levels were significantly elevated in the CPB cases (0.18±0.41 ng/ml-1 before CVS to 5.50±5.49 ng/ml-1 after CPB). Patients undergoing CVS with CPB had significantly elevated serum S-100β levels when compared with post-operative levels in CVS cases without CPB. One case of brain injury after CVS had higher levels of serum S-100β than all post-CPB cases with no brain injury.
Conclusion. These results suggest that in patients undergoing CVS with CPB, serum S-100β protein levels may not be a clear indicator immediately after CPB. However, they may be useful in CVS without CPB. Because long time is required for getting the results of measurement, serum S-100β may not be useful for early diagnosis of brain injury.