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A Journal on Surgery
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Chirurgia 2008 June;21(3):135-8
Changes in serum S-100β after cardiovascular surgery
Takeuchi K. I., Sakamoto S., Nagayoshi Y., Nishizawa H., Noguchi Y., Kiyosawa J., Matsubara J.
Department of Thoracic and Cardiovascular Surgery Kanazawa Medical University, Ishikawa, Japan
Aim. Serum S-100β protein is an early marker of brain injury following cardiovascular surgery (CVS). In this report, we investigated the changes in serum S-100β protein after CVS.
Methods. 75 cases of CVS with cardiopulmonary bypass (CPB) and 6 cases of CVS without CPB (off-pump coronary artery bypass grafting) were followed between October 2002 and December 2004. S-100β was measured before CVS, directly after weaning from CPB, and at 6, 12 and 24 hours after the end of CPB.
Results. Mean S-100β levels were significantly elevated in the CPB cases (0.18±0.41 ng/ml-1 before CVS to 5.50±5.49 ng/ml-1 after CPB). Patients undergoing CVS with CPB had significantly elevated serum S-100β levels when compared with post-operative levels in CVS cases without CPB. One case of brain injury after CVS had higher levels of serum S-100β than all post-CPB cases with no brain injury.
Conclusion. These results suggest that in patients undergoing CVS with CPB, serum S-100β protein levels may not be a clear indicator immediately after CPB. However, they may be useful in CVS without CPB. Because long time is required for getting the results of measurement, serum S-100β may not be useful for early diagnosis of brain injury.