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A Journal on Surgery
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Chirurgia 2007 June;20(3):141-3
Giant benign true cysts of the spleen with high serum levels of tumor markers
Vadalà S., Lodin M., Pappalardo A., Giannone G., Cinardi N.
Unit of Surgical Oncology, Department of Oncology G. Garibaldi Hospital, Catania, Italy
The relation between splenic cysts and tumor markers has been extensively investigated, however the precise clinical relevance and significance have not been fully understood. The present study was designed to evaluate the levels of tumoral markers in patients with splenic cysts. Furthermore, we assessed the differences of tumoral markers levels before and after surgical procedures and how these markers correlate to intracystyc markers levels. We present two case report describing two patients affected by splenic cysts. Blood samples were collected before and after splenic cysts removal and analyzed for the presence of CA 19.9, CA 125 and CEA. Splenic cysts were removed and analyzed for histological analysis and intracystic tumoral markers levels.
Our results showed that tumor markers levels were abnormally higher in our patients and were normalized following spleen removal. Our results demonstrated that patients affected by benign splenic cysts show that they are to correlate to the cysts and not to oncological diseases. Elevated level of tumor markers (Ca19-9) are associated with splenic cysts.