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A Journal on Surgery
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Chirurgia 2006 February;19(1):19-22
Erythropoietin exerts myocardial protection after brain injury in rats: effect on ultra structural findings
Ozisik K. 1, Yildirim E. 1, Emir M. 2, Kaplan S. 2, Bakuy V. 2, Okutan O. 3, Sargon M. F. 4, Koçer B. 1, Aydin H. 1
1 Department of Cardiovascular Surgery Ankara Numune Education and Research Hospital Ankara, Turkey
2 Department of Cardiovascular Surgery, TYIH, Ankara, Turkey
3 Department of Neurosurgery, Ankara Numune Education and Research Hospital, Ankara, Turkey
4 Department of Anatomy, Faculty of Medicine Hacettepe University, Ankara, Turkey
Aim. The purpose of this study was to evaluate the protective effect of erythropoietin (EPO) on cardiac myocytes’ ultrastructure against damage in rats after traumatic brain injury (TBI).
Methods. Forty Wistar-Albino female rats weighing 170-200 g were randomly allocated into 5 groups. Group 1 was the control and Group 2 was the sham operated group. Group 3 received head trauma and no treatment. The fourth and fifth groups were erythropoietin (1000 IU/kg) and vehicle (0,4 ml/rat) groups, respectively. Weight-drop technique was used for achieving traumatic brain injury. Samples were obtained from the the left ventricle 24 hour after trauma. An electron microscopic scoring model was used to grade the subcellular changes.
Results. Electron microscopic findings showed that traumatic brain injury increased nucleus, sarcoplasmic reticulum, and mitochondria scores significantly (p<0.05). Treatment whether with erythropoietin or vehicle solution does not protect sarcoplasmic reticulum after trauma (p>0.05). Despite of these findings, erythropoietin decreased nucleus and mitochondria scores significantly after trauma (p<0.05).
Conclusion. These findings suggest that erythropoietin protects the ultrastructure of cardiac myocytes of rats against damage after traumatic brain injury.