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A Journal on Surgery

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Chirurgia 2005 April;18(2):93-8

language: Italian

Duodenal and pancreatic neuro-endocrine tumors: update and clinical series

Bergamini B., Borrelli A., Presenti L., Borrelli D.


The authors examined the state of art of the neuro-endocrine tumors of the duodenal-pancreatic area, which is an issue of increasing interest by the clinical and the biological reasearch. Furthermore, through the presentation of a personal series of 17 patients, who have been operated since 1994 up to 2004 at the General and Vascular Surgery Department of Careggi Hospital in Florence, the authors make some observations concerning the evolution of the diagnostic and the therapeutic approach to these pathologies during the last years. Both the correct application of the preoperative imaging techniques, which have to be particularly efficient and clear, and the wide extension of the surgical indications, which have to be applied even for locally advanced tumors, seem to play a key role for a definitive success in the therapy of such neoplasms. In particular, regarding the imaging, the authors remark the important role of the scan techniques which are able to identify most of the neuro-endocrine tumors, using a radio-labeled somatostatin derivative octreotide, the insulinoma being the only entity who does not usually share any receptors for this substance. Finally, the importance of the medical therapy using somatostatin derivative, such as octreotide, is outlined. This treatment is to be done alone or as a completion of the surgical therapy, for the most locally advanced disease. Such a combining approach is able to offer encouraging results in the treatment of these uncommon entities.

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