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Chirurgia 2004 June;17(3):95-8

language: English

Spontaneous regression of hepatocellular carcinoma. A case report

Erturk S., Yuceyar S., Yigitbasi R., Onur E., Saner H., Uygun N.


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In our 69-year-old male patient, a solid tumor, 9 cm in diameter, was detected in the left lobe of the liver by abdominal ultrasonography (US) and computed tomography (CT). These imaging studies also revealed thickened falciform ligament and ascites indicating peritoneal dissemination. Hepatitis B surface antigen was positive and he had elevated alfa-fetoprotein (AFP) level. Percutaneous fine needle liver biopsy revealed hepatocellular carcinoma (HCC). The case was considered to be inoperable and patient refused to take any medical or interventional help. Therefore, he was kept under observation without treatment at the outpatient regularly. Two years later, neither tumor nor ascites was detected by control abdominal CT. AFP level was also in normal ranges. The patient is alive, without evidence of recurrence at last control, 3 years after the initial diagnosis. Cases of spontaneous regression of HCC have rarely been observed and reported, and our patient with documented HCC also fulfilled the criteria of Everson and Cole for spontaneous regression of malignant tumors.

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