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A Journal on Surgery


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Chirurgia 2004 April;17(2):63-6

language: English

Surgical excision combined with cadaveric allografts and Tazarotene in the management of a patient with nevoid basal cell carcinoma syndrome

Andreassi A., Castelli C., Souvatzidis P., D'Aniello C., Bilenchi R., Pianigiani E.


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Basal-cell nevus syndrome (BCNS) is an inherited condition marked by multiple basal cell carcinomas (BCCs) associated with several other abnormalities. Various treatment modalities have been used to eradicate these tumors. However, recurrences and scarring limit their use. A case of BCNS in which multiple BCCs were effectively treated with surgical excision and covering of the wounds with homologous glycerol-preseved skin grafts, is described. Moreover, in order to avoid recurrences, the patient was treated with topical tazarotene 0.1% cream. The patients was effectively treated with this combination therapy and minimal scarring was noted at follow-up. Homologous skin grafts and tazarotene can be used to effectively treat BCCs associated with BCNS, with minimal post-treatment scarring.

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