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A Journal on Surgery

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Chirurgia 1999 August;12(4):301-6

language: Italian

Chemotherapy (5-fluorouracil and folinic acid) in addition to surgical treatment of colorectal neoplasms

Longhini A., Landucci A., Borelli P., Kazemin A., Tessi W., Marcolli G.


A retrospective study is made on the effects of chemotherapy on survival of patients with colorectal cancer who underwent resective surgery. The chemotherapeutic regimen was an association of 5-fluorouracil with folinic acid. In patients with stage II disease no benefit was derived by adding chemotherapy after operation, while survival was longer for patients with stage III-IV who received chemoterapy: the five-year survival rate for stage III was 62% for adjuvant chemotherapy versus 31% for surgery alone (p=0.99) and the two-year survival rate for stage IV was 33% for palliative chemotherapy versus 7% for surgery alone (p<0.001). All patients with node-positive (stage III) or metastatic (stage IV) colorectal cancer, should receive chemotherapy after operation, since it improves the results of therapy, as compared with surgery alone.

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