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Chirurgia 1999 August;12(4):287-90

language: English

Microscopic changes in the hepatocyte and MEGX test as early markers of cell damage related to warm ischemic conditions in porcine model

Gruttadauria S., Marino G., Gentile A., Sgroi A. V., Pintaudi S., Libra S., Gruttadauria G.


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There is experimental and clinical evidence that livers can normally tolerate warm ischemic conditions for more than 60'. However totally reliable molecular markers of early cell damage related to warm ischemic conditions are currently not available. The aim of this study was to assess early microscopic changes and functional capacity impairment after exposure to warm ischemic conditions of experimentally transplanted livers in the porcine model. MEGX test is currently used to assess the degree of liver cell damage after exposure to warm ischemic conditions. It has been found that within 30' of warm ischemic conditions the serum levels of ALT, AST and MEGX are still normal but after 30' of warm ischemic conditions MEGX test reveals a degree of impairment of liver function capacity. Microscopic changes in livers exposed to warm ischemic conditions for not longer than 30' are minimal. However, hepatocyte necrosis and plasm cell infiltration have been found in biopsies taken from livers in transplanted animals after 60' of warm ischemia.

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