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A Journal on Surgery

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Chirurgia 1999 April;12(2):131-4

language: Italian

Radiation induced soft tissue sarcoma occurring in breast cancer patients and review of the literature

Frattini V., Barbera D., Rampi R., Giardina G., Bardelli D., Colombo L.


Soft tissue sarcomas secondary to radiation therapy for breast cancer count approximately for 0,2%. The case of a patient affected by soft tissue sarcoma diagnosed after radiation therapy for breast cancer is reported: the clinical aspects of the case are compared with the data found in literature. In this patient the development of little size node in the mid-axillary line, led to the diagnosis of sarcoma; surgical treatment of the tumor led to a complete remission, and no other therapy was necessary. The review of the literature shows that the development of soft tissue sarcoma secondary to radiotherapy in patients operated on for breast cancer, varies on a wide range. The efficacy of radiation doses and different therapies are discussed. This case report suggests that surgery could lead to a complete remission of the disease, and that this procedure is also nowadays the best means of palliation, while other procedures, such as chemotherapy, do not give satisfactory results.

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