Home > Journals > Italian Journal of Maxillofacial Surgery > Past Issues > Italian Journal of Maxillofacial Surgery 2014 December;25(2-3) > Italian Journal of Maxillofacial Surgery 2014 December;25(2-3):65-8

CURRENT ISSUEITALIAN JOURNAL OF MAXILLOFACIAL SURGERY

A Journal on Maxillofacial Surgery


Official Journal of the Italian Society of Maxillofacial Surgery


eTOC

 

CASE REPORTS  


Italian Journal of Maxillofacial Surgery 2014 December;25(2-3):65-8

language: English

Bisphosphonate-related osteonecrosis of the jaw: when surgery may be necessarys

Chiodi S. 1, Carta M. 1, Iacoviello P. 1, Signorini G. 1, Guglielmini P. 2, Fusco V. 2, Grosso F. 2, Piovano P. L. 2, Verrina G. 1

1 Unit of Maxillofacial Surgery, Ente Ospedaliero Ospedali Galliera, Genova, Italy;
2 Unit of Medical Oncology, Azienda Ospedaliera Nazionale “SS. Antonio e Biagio e C. Arrigo”, Alessandria, Italy


PDF  REPRINTS


Osteonecrosis of the jaw (ONJ) is a rare adverse event of treatment with nitrogen-containing bisphosphonates (N-BPs) in metastatic cancer patients, which can negatively affect the patient’s quality of life and its management is still difficult. We here report the case of a patient with metastatic breast cancer who had been treated for many years with zoledronic acid ending in ONJ. The patient was referred to our Centre for an ascessual lesion with orocutaneous fistula, along with pain and inability to swallow, unresponsive to antibiotic therapy and surgical debridements. She underwent a left subtotal hemimandibulectomy with reconstruction. After surgery the pain disappeared and re-alimentation was achieved. The case points out that, in truly advanced ONJ, only a demolitive surgical approach can be effective.

top of page