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ITALIAN JOURNAL OF MAXILLOFACIAL SURGERY

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Rivista Italiana di Chirurgia Maxillo-Facciale 2005 January-December;16(1-3):73-6

Copyright © 2006 EDIZIONI MINERVA MEDICA

language: English

Thyroglossal duct cyst cancer. Case report

Tullio A. 1, Meloni S. M. 2, Festa A. 3, De Riu G. 1

1 Department of Maxillofacial surgery University of Sassari, Sassari, Italy 2 Dental Department University of Sassari, Sassari, Italy 3 Department of Surgical Pathology University of Sassari, Sassari, Italy


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Incomplete involution of the thyroglossal duct results in embryonic vestiges that may give rise to thyroglossal duct cysts. Thyroglossal duct cyst is the most common congenital cystic neoformation of the neck, accounting for about 70% of cases. Less than 1% of thyroglossal duct cysts are supposed to undergo malignant changes; 80% of these cases are papillary carcinomas. Metastasis to the regional lymph nodes has been reported in 7.7% to 12.9 % of malignant cases , much less frequently than primary papillary carcinomas of the thyroid gland.. There are two types of thyroglossal duct carcinomas, thyrogenic carcinomas and squamous cell carcinoma. The former most likely arises from thyroembryonic remnants in the duct or cyst, and the latter from metaplastic cuboidal cells. The papillary carcinoma is the most common type (80%), followed by mixed papillary-follicular carcinoma (8%) and squamous cell carcinoma (6%), the remaining includes rare cases of follicular and anaplastic carcinomas. In literature have been reported about 150 malignant cases. In this article we describe a rare disease that can be confused with a common thyreoglossal duct cyst .

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