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ITALIAN JOURNAL OF MAXILLOFACIAL SURGERY
A Journal on Maxillofacial Surgery
Official Journal of the Italian Society of Maxillofacial Surgery
Rivista Italiana di Chirurgia Maxillo-Facciale 2002 December;13(3):155-61
Fibrin glue and platelet-rich plasma in maxillo-facial surgery. Preparation method and clinical and radiological TC follow-up
Cortese A., Saturno M., Savastano G.
Department of Maxillo-Facial Surgery Federico II University, Naples, Italy
Aim. This research aimed to evaluate a method for the production of fibrin glue (FG) and platelet-rich plasma (PRP) developed by the Immunohaematology and Transfusion Service, Federico II University, Naples. The results of employing FG and PRP during reconstructive surgery for bone augmentation were evaluated.
Methods. Twelve patients programmed for bone augmentation surgery were subdivided into 2 groups of 6 patients, each containing four patients operated 4 major sinus lift and 2 by autologous calvaria graft. Patients in Group I underwent surgery without FG and PRP whereas those in Group II received FG and PRP; 300 ml of blood were withdrawn from each patient in Group II for preparation of FG and PRP.
Results. Mean fibrinogen concentration in FG was 1100-1200 mg/dl. Mean concentration in PRP was 1×109±0.5. Concentration was increased by 415.7% for FG and 380, 228% for PRP. Bone resorption of grafts at 1 year was 10% less in sinus lift operations using FG and PRP and 15% less in calvaria bone grafts using FG and PRP.
Conclusion. The results show that this safe, sterile, rapid and cheap preparation method for FG and PRP improves bone graft survival and reduces infection rate.