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ITALIAN JOURNAL OF MAXILLOFACIAL SURGERY
A Journal on Maxillofacial Surgery
Official Journal of the Italian Society of Maxillofacial Surgery
Rivista Italiana di Chirurgia Maxillo-Facciale 2002 December;13(3):143-6
DNA ploidy of ameloblastoma of the jaws
Messi M. 1, Ascani G. 1, Balercia P. 1, Giacomini P. R. 1, Romagnoli D. 1, Rubini C. 2, Colanzi P. 2
1 Operative Unit of Maxillo-Facial Surgery, Torrette Regional Hospital, Ancona, Italy
2 Department of Anatomy and Histopathology, University of Ancona, Ancona, Italy
Aim. Ameloblastoma is the commonest benign odontogenic tumor. It’s a benign neoplasia, but locally aggressive. The histologic patterns are follicular, plexiform, acanthomatous, desmoplastic and granular cells. Clinical variants are 2: solid and cystic. Ameloblastic carcinoma shows histologic features of malignancy. The aim of this study is to evaluate the nuclear DNA content of ameloblastomas and its correlation to the histological type and the different clinical behaviour.
Methods. By image cytometric analysis of sections from formalin-fixed, paraffin embedded tumors, we compared nuclear DNA content of 15 ameloblastomas.
Results. Twelve of 15 ameloblastomas showed cells with normal diploid DNA content (DNA-index: 1.00). Three cases were uninterpretable. The coefficient of variation (CV) ranged from 5.21% to 7.65% (mean 6.43%). The percentage of S-phase ranged from 5.21% to 13.64% with mean of 9.42%.
Conclusion. No significant difference in ploidy between primary and recurrent ameloblastomas was demonstrated, while increasing S-phase percent was associated with malignant trasformation in 1 case.