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Rivista Italiana di Chirurgia Maxillo-Facciale 2002 December;13(3):143-6

Copyright © 2003 EDIZIONI MINERVA MEDICA

language: English

DNA ploidy of ameloblastoma of the jaws

Messi M. 1, Ascani G. 1, Balercia P. 1, Giacomini P. R. 1, Romagnoli D. 1, Rubini C. 2, Colanzi P. 2

1 Operative Unit of Maxillo-Facial Surgery, Torrette Regional Hospital, Ancona, Italy 2 Department of Anatomy and Histopathology, University of Ancona, Ancona, Italy


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Aim. Ameloblastoma is ­the com­mon­est ­benign odon­to­gen­ic ­tumor. It’s a ­benign neo­pla­sia, ­but local­ly aggres­sive. The his­to­log­ic pat­terns ­are fol­lic­u­lar, plex­i­form, acan­thom­a­tous, des­mo­plas­tic ­and gran­u­lar ­cells. Clinical var­i­ants ­are 2: sol­id ­and cys­tic. Ameloblastic car­ci­no­ma ­shows his­to­log­ic fea­tures of malig­nan­cy. The ­aim of ­this ­study is to eval­u­ate ­the nucle­ar ­DNA con­tent of amel­o­blas­to­mas ­and ­its cor­re­la­tion to ­the his­to­log­i­cal ­type ­and ­the dif­fer­ent clin­i­cal beha­vi­our.
Methods. By ­image cyto­met­ric anal­y­sis of sec­tions ­from for­mal­in-­fixed, par­af­fin embed­ded ­tumors, we com­pared nucle­ar ­DNA con­tent of 15 amel­o­blas­to­mas.
Results. Twelve of 15 amel­o­blas­to­mas ­showed ­cells ­with nor­mal dip­loid ­DNA con­tent (­DNA-­index: 1.00). Three ­cases ­were unin­ter­pret­able. The coefficient of variation (CV) ­ranged ­from 5.21% to 7.65% (­mean 6.43%). The per­cent­age of S-­phase ­ranged ­from 5.21% to 13.64% ­with ­mean of 9.42%.
Conclusion. No sig­nif­i­cant dif­fer­ence in ­ploidy ­between pri­mary ­and recur­rent amel­o­blas­to­mas ­was dem­on­strat­ed, ­while increas­ing S-­phase per­cent ­was asso­ciat­ed ­with malig­nant tras­for­ma­tion in 1 ­case.

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