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ITALIAN JOURNAL OF MAXILLOFACIAL SURGERY
A Journal on Maxillofacial Surgery
Official Journal of the Italian Society of Maxillofacial Surgery
Rivista Italiana di Chirurgia Maxillo-Facciale 2001 April;12(1):33-6
Small cell neuroendocrine carcinoma of the parotid gland. A clinico-pathological report with immunohistochemical and ultrastructural study
Califano L., Mignogna M. D., Longo F., Mangone G. M., Giardino C.
From the Department of Oral and Maxillo-facial Surgery, University of Naples “Federico II”, School of Medicine, Naples, Italy
Small cell carcinoma (SCC) of the salivary glands is a very rare tumor. The most common site of SCC is lung (96%) and only rarely extrapulmonary sites have been described. SCC is divided into two types: those with intracytoplasmatic granules (Small cell neuroendocrine carcinoma), and those without (Small cell ductal carcinoma). This distinction has a prognostic and therapeutic value. Thus far immunohistochemical assay and/or electron microscopy have been thought to be essential for the diagnosis of SCC. A case of SCC with neuroendocrine features demonstrated by both immunohistochemical assay and electron microscopy is reported. Our findings stress the importance of immunohistochemistry that can be more sensitive and useful than transmission electron microscopy.