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ITALIAN JOURNAL OF MAXILLOFACIAL SURGERY
A Journal on Maxillofacial Surgery
Official Journal of the Italian Society of Maxillofacial Surgery
Rivista Italiana di Chirurgia Maxillo-Facciale 2001 April;12(1):3-7
Vertical augmentation in severe atrophic mandible: osteogenesis distraction and platelet-rich plasma (PRP)
Robiony M., Polini F., Costa F., Pasca S. *, Politi M.
From the Department of Maxillo-Facial Surgery Faculty of Medicine, University of Udine, Udine, Italy
* Transfusional Medicine Hospital of Udine, Udine, Italy
The aim of this article is to propose a new method for restoring severe atrophic mandible using platelet-rich plasma (PRP) during alveolar ridge distraction. Before surgical intervention venous blood is drawn from the patient in order to obtain a platelet concentrate as a source of growth factors, such as PDGF or TGF β. Such molecules derived from platelets, seem to be the main factors that initiate connective tissue healing, including bone regeneration and repair. Considering that tissue engineering generally combines three key elements as matrices, signaling molecules (growth factors) and cells, we harvest a cancellous bone graft from the iliac crest to obtain the scaffold for complete bone regeneration. So, during the surgical act, the distraction space is filled up by a mixture consisting in the bone graft and the autologous platelet concentrate (APC) just obtained from PRP. Such a mixture, named autologous bone-platelet gel (ABPG), used as scaffold in new bone regeneration during distraction osteogenesis, seems to ensure an adequate mandibular restoration and permits an implant placement just 60 days after the end of the distraction run.