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A Journal on Cardiac, Vascular and Thoracic Surgery

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The Journal of Cardiovascular Surgery 2016 Oct 04


language: English

Trans-axillary versus trans-aortic approach for transcatheter aortic valve implantation with corevalve revalving system: insights from multicentre experience

Claudia FIORINA 1, Giuseppe BRUSCHI 2, Luca TESTA 3, Marco DE CARLO 4, Federico De MARCO 3, Giuseppe COLETTI 1, Stefano BONARDELLI 1, Marianna ADAMO 1, Salvatore CURELLO 1, Giovanni SCIOTI 4, Paolo PANISI 3, Francesco BEDOGNI 3, Anna S. PETRONIO 4, Federica ETTORI 1

1 Cardiothoracic Department, Spedali Civili Brescia, Brescia, Italy; 2 Niguarda Ca’ Granda Hospital, Milan, Italy; 3 IRCCS Policlinico S.Donato, Milan, Italy; 4 Azienda Ospedaliero Universitaria Pisana, Pisa, Italy


BACKGROUND: About one-third of candidates for transcatheter aortic valve implantation (TAVI) suffer from severe peripheral artery disease, making the routine femoral approach difficult or impossible. Aim was to compare the trans-axillary (TAx) and the trans-aortic (TAo) route for TAVI with Medtronic CoreValve Revalving System (CRS).
METHODS: 242 (23%) out of 1049 consecutive TAVI with 18F CRS were treated in 4 high-volume Italian Centre through TAx (61%) and TAo (39%).
RESULTS: The devices success was similar (p=0.16) with a trend to a lower incidence of significant paravalvular leak (6% vs 14%, p=0.07) and a significant reduction of permanent pacemaker (PPM) implantation (13% vs 34%, p=0.017) in the TAo. However, this route showed a higher incidence of acute kidney injury (p=0.016) and a longer hospital stay after the index procedure (days 10 [8-14] vs 8 [7-12], p=0.001). By a multivariate analysis the vascular access is an independent predictor for a longer hospital stay (TAo route; OR= 0.37, 95%CI 0.18-0.75; p=0.006) and for PPM implantation (TAx route; OR= 3.7, 95% CI 1.2-10.8; p=0.017).
CONCLUSIONS: Although the higher clinical risk profile of trans-aortic population, the TAo approach showed an equally high device success with similar 30-day safety and 1year efficacy, compared to TAx route. However, due to non procedure-specific complications post-TAo TAVI, this route requires a specialized postoperative care and the treatment of patients in highly specialized and experienced centres.

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