Home > Journals > The Journal of Cardiovascular Surgery > Past Issues > The Journal of Cardiovascular Surgery 2016 February;57(1) > The Journal of Cardiovascular Surgery 2016 February;57(1):18-22

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

THE JOURNAL OF CARDIOVASCULAR SURGERY

A Journal on Cardiac, Vascular and Thoracic Surgery


Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,179


eTOC

 

REVIEWS  NEW DEVELOPMENTS WITH DRUG-ELUTING BALLOONS


The Journal of Cardiovascular Surgery 2016 February;57(1):18-22

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Drug coated balloons below-the-knee: just too early?

Fabrizio FANELLI 1, Alessandro CANNAVALE 2

1 Vascular and Interventional Unit, Department of Radiological Sciences, “Sapienza” University of Rome, Rome, Italy; 2 Vascular and Interventional Unit, Department of Radiology, East Kent Hospitals University NHS Foundation Trust, Canterbury, UK


PDF  


Patients with infrapopliteal arterial disease are generally considered challenging due to the usual presence of multivessel atherosclerotic disease. Several treatment options have been used by different authors but none of them can be considered ideal. In the last few years drug coated balloons have gained popularity especially due to the extraordinary results in the femoro-popliteal region. Following the great success, physicians started to use this promising device also in the below-the-knee (BTK) region. The initial enthusiasm correlated to some studies is not confirmed by the largest randomized trial, IN.PACT Deep, comparing In.Pact DCB to standard PTA. This trial failed completely to show the superiority of drug coated balloon (DCB). The negative outcome was mainly correlated to safety issues with an amputation rate higher for the drug coated balloon when compared to the conventional balloon (8.8% DCB vs.3.6% PTA, P=0.08). A thorough evaluation has been performed to justify these negative outcomes, given the good results reported by other studies. But nowadays it is still difficult to find a clear explanation. Especially for this negative outcome and for the big difference, in term of results, between the different studies in the BTK region and also between the above and below the knee regions more trials are mandatory.

top of page

Publication History

Cite this article as

Corresponding author e-mail

fabrizio.fanelli@uniroma1.it