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Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632
Online ISSN 1827-191X
Van Lammeren G. W. 1, 2, Van De Mortel R. H. 1, Visscher M. 1, Pasterkamp G. 2, De Borst G. J. 3, Moll F. L. 3, Vink A. 4, Tromp S. C. 5, De Vries J.-P. P. M. 1
1 Department of Vascular Surgery, St. Antonius Hospital Nieuwegein, The Netherlands;
2 Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands;
3 Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands;
4 Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands;
5 Department of Clinical Neurophysiology, St. Antonius Hospital, Nieuwegein, The Netherlands
AIM: Carotid plaque composition is associated with ipsilateral cerebrovascular events. Among patients with carotid artery stenosis, presence of microembolic signals (MES) detected with transcranial Doppler (TCD) is associated with increased stroke risk. We aimed to investigate whether MES detected with TCD in the outpatient clinic among patients scheduled for carotid endarterectomy, was associated with underlying carotid plaque composition.
METHODS: TCD was used to detect MES among 38 symptomatic patients scheduled for carotid endarterectomy. Measurements were performed for 30 minutes. Carotid plaques harvested during CEA were subjected to histopathological examination. Plaques from patients without spontaneous MES were compared with plaques from patients with ≥1 MES.
RESULTS: Median time between TCD and surgery was 4 days. At least 1 MES was detected in 10/38 (26%) patients. Five of ten (50%) patients with spontaneous MES had lipid-rich plaques, compared with 5/28 (17.2%) plaques from patients without MES (P=0.048). Luminal thrombus was observed in 6/10 (60.0%) of plaques from patients with MES compared with 7/28 (25.0%) of plaques from patients without MES (P=0.045).
CONCLUSION: Spontaneous MES were detected in 26% of symptomatic patients scheduled for CEA and were associated with unstable carotid plaque characteristics. TCD might be a useful tool to help identify patients with vulnerable plaques.