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McLean R. C. 1, Nazarian S. M. 1, Gluckman T. J. 1, Schulman S. P. 1, Thiemann D. R. 1, Shapiro E. P. 1, Conte J. V. 1, Thompson J. B. 1, Shafique I. 1, McNicholas K. W. 2, Villines T. C. 3, Laws K. M. 1, Rade J. J. 1
1 Johns Hopkins School of Medicine, Baltimore, MD, USA;
2 Christiana Research Institute, Christiana, DE, USA;
3 Walter Reed Army Medical Center, Washington, DC, USA
AIM: The aim of the present study was to investigate the relative importance of a wide array of patient demographic, procedural, anatomic and perioperative variables as potential risk factors for early saphenous vein graft (SVG) thrombosis after coronary artery bypass graft (CABG) surgery.
METHODS:The patency of 611 SVGs in 291 patients operated on at four different hospitals enrolled in the Reduction in Graft Occlusion Rates (RIGOR) study was assessed six months after CABG surgery by multidetector computed tomography coronary angiography or clinically-indicated coronary angiography. The odds of graft occlusion versus patency were analyzed using multilevel multivariate logistic regression with clustering on patient.
RESULTS: SVG failure within six months of CABG surgery was predominantly an all-or-none phenomenon with 126 (20.1%) SVGs totally occluded, 485 (77.3%) widely patent and only 16 (2.5%) containing high-grade stenoses. Target vessel diameter ≤1.5 mm (adjusted OR 2.37, P=0.003) and female gender (adjusted OR 2.46, P=0.01) were strongly associated with early SVG occlusion. In a subgroup analysis of 354 SVGs in which intraoperative graft blood flow was measured, lower mean flow was also significantly associated with SVG occlusion when analyzed as a continuous variable (adjusted OR 0.984, P=0.006) though not when analyzed dichotomously, <40 mL/min versus ≥40 mL/min (adjusted OR 1.86, P=0.08).
CONCLUSION:Small target vessel diameter, female gender and low mean graft blood flow are significant risk factors for SVG thrombosis within six months of CABG surgery in patients on postoperative aspirin therapy. This information may be useful in guiding revascularization strategies in selected patients.