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The Journal of Cardiovascular Surgery 2010 December;51(6):923-7

language: English

Unchanged heat-shock protein 70 expression in myocardium of patients with permanent atrial fibrillation

Schäfler A. E., Hannekum A., Kirmanoglou K.

Department of Cardiac Surgery, University of Ulm,, Ulm, Germany


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AIM: Cardiomyocytes respond to permanent atrial fibrillation (AF) with an increase in mitochondrial heat shock proteins (Hsp). The aim of our study was to test if there is a cytoplasmic response to stress by investigating the expression of Hsp70.
METHODS: Right atrial samples from 18 patients undergoing elective cardiac surgery were excised and immediately frozen in liquid nitrogen. Eight patients had permanent AF (>3 months) and 10 patients were in sinus rhythm (SR). Hsp70 was determined by SDS-PAGE, Western blot and quantified with optical densitometry.
RESULTS: We found no increase in Hsp70 expression in myocardial samples from patients with permanent AF.
CONCLUSION: The unchanged expression of Hsp70 may indicate that the cytoplasmic stress response in permanent AF is exhausted.

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aschaefler@gmx.de