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CURRENT ISSUETHE JOURNAL OF CARDIOVASCULAR SURGERY

A Journal on Cardiac, Vascular and Thoracic Surgery

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632

Frequency: Bi-Monthly

ISSN 0021-9509

Online ISSN 1827-191X

 

The Journal of Cardiovascular Surgery 2008 October;49(5):627-31

VASCULAR SECTION 

    ORIGINAL ARTICLES

Protective effect of sivelestat sodium (Eraspol®) on postoperative lung dysfunction in patients with type A acute aortic dissection: a pilot study

Nishibe T. 1, Kondo Y. 1, Muto A. 2, Dardik A. 2, Ohara Y. 3, Kainuma M. 3, Takeda K. 3

1 Division of Cardiovascular Surgery Department of Surgery Fujita Health University, Toyoake, Japan
2 Department of Vascular Surgery Yale University School of Medicine New Haven, CT, USA
3 Department of Anesthesiology Fujita Health University, Toyoake, Japan

Aim. The authors evaluated the protective effect of sivelestat sodium on postoperative lung dysfunction in patients with type A acute aortic dissection who underwent aortic arch surgery with cardiopulmonary bypass (CPB) under deep hypothermia with circulatory arrest (DHCA).
Methods. Twelve patients with type A acute aortic dissection who underwent aortic arch replacement under CPB with DHCA and were pretreated with or without sivelestat sodium (sivelestat group, N.=7 patients; control group, N.=5 patients) were observed. The ratio of arterial oxygen tension to inspired oxygen fraction (P/F ratio) was measured as a parameter of pulmonary function before and after operation. The number of white blood cells was also counted as an index of inflammatory reaction before and after the operation.
Results. The P/F ratio decreased significantly after operation in the control group. However, the P/F ratio was unchanged between before and after operation in the sivelestat group. The number of white blood cells tended to increase after operation in the control group, whereas it decreased significantly after operation in the sivelestat group.
Conclusion. The present study demonstrated the protective effect of sivelestat sodium on postoperative lung injury in patients with acute type A aortic dissection undergoing aortic arch surgery under CPB with DHCA.

language: English


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