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THE JOURNAL OF CARDIOVASCULAR SURGERY

A Journal on Cardiac, Vascular and Thoracic Surgery


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The journal of Cardiovascular Surgery 2004 December;45(6):585-7

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Synchronous independent bifocal orthotopic thymomas. A case report

Nonami Y. 1, Moriki T. 2

1 Department of Surgery II, Kochi Medical School, Kohasu Nankoku, Kochi, Japan 2 Department of Clinical Laboratory Kochi Medical School, Kohasu, Nankoku, Kochi, Japan


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A case of synchronous multiple thymomas is reported. The patient was an 81-year-old woman with 2 separate thymomas in the anterior mediastinum. A histological study revealed that both thymomas consisted of dense lymphocyte infiltration in the stroma and a small number of polygonal epithelial tumor cells with clear nuclei and distinct nucleoli. Immunohistochemical staining using the antibodies to 2 antigens, bcl-2, and MIB-1 showed identical staining patterns. In spite of these findings, we considered their origin to be synchronous multicentric development rather than intra-thymic metastasis, based on the non-invasive nature of these tumors.

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