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The Journal of Cardiovascular Surgery 2003 October;44(5):611-5

language: English

The effects of heparin coated circuits on pulmonary injury. A clinical study

Kazaz H., Oto Ö., Sariosmanoˇglu N., Hazan E.

Depart­ment of Tho­racic and Car­di­o­vas­cular Sur­gery, Uni­ver­sity of ­Dokuz ­Eylül, ­Izmir, ­Turkey


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Aim. Hep­arin-­coated cir­cuits ­have dra­matic ­effects on the coag­u­la­tion cas­cade, but ­their ­role on com­ple­ment acti­va­tion has not ­been ­clearly ­defined. In ­this clin­ical ­study the ­effect of hep­arin-­coated cir­cuits on ­static ­lung com­pli­ance and pul­mo­nary vas­cular resis­tance is ­described.
­Methods. ­Thirty ­patients ­were ran­domly ­divided ­into two ­groups: ­with ­either a hep­arin-­coated cir­cuit or an iden­tical but non-­coated cir­cuit con­trol ­group. In the hep­arin-­coated ­group, all the ­blood con­tacting sur­faces ­were ­treated ­with immo­bi­lized hep­arin (­Duraflo II.)
­Results. ­Early post­op­er­a­tive pul­mo­nary func­tion is deter­mined ­with meas­ure­ments of ­static ­lung com­pli­ance, pul­mo­nary vas­cular resis­tance and arte­rial ­blood ­gases. ­Static ­lung com­pli­ance was sig­nif­i­cantly ­better in the hep­arin ­coated (HC) ­group in the ­early post­op­er­a­tive ­period (p=0.001). Pul­mo­nary vas­cular resis­tance was sig­nif­i­cantly ­lower in the hep­arin-­coated (HC) ­group in the ­early post­op­er­a­tive ­period (p=0.001).
Con­clu­sion. We ­believe ­that the ­method of hep­arin ­binding may ­play a ­role in its dimin­ished ­effect on com­ple­ment acti­va­tion, but the gen­eral aug­men­ta­tion of the ­circuit’s bio­com­pat­ibility may ­explain its ben­e­fi­cial ­effect on pul­mo­nary vas­cular resis­tance and ­static ­lung com­pli­ance.

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