Home > Journals > The Journal of Cardiovascular Surgery > Past Issues > The Journal of Cardiovascular Surgery 2003 April;44(2) > The Journal of Cardiovascular Surgery 2003 April;44(2):191-6

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

THE JOURNAL OF CARDIOVASCULAR SURGERY

A Journal on Cardiac, Vascular and Thoracic Surgery


Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632


eTOC

 

ORIGINAL ARTICLES  CARDIAC SECTION


The Journal of Cardiovascular Surgery 2003 April;44(2):191-6

language: English

Do we still need CK-MB in coronary artery bypass grafting surgery?

Bimmel D., Patermann B., Schlosser T., Winkler K., Tiemann K., Likungu J. A., Preusse C. J., Welz A.

Depart­ment of Car­diac Sur­gery, Uni­ver­sity of ­Bonn, ­Bonn, Ger­many


PDF  


Aim. The aim of ­this ­study was to eval­uate the ­role of car­diac Tro­ponin I (­cTnI) and CK-MB for ­early pre­dic­tion of out­come of ­patients under­going coronary artery bypass grafting (­CABG) sur­gery.
­Methods. In 134 con­sec­u­tive ­patients under­going ­CABG-sur­gery ­blood sam­ples ­were ana­lyzed for ­cTnI con­cen­tra­tion and CK-MB ­activity. ECG, hemo­dy­namic param­e­ters and the ­need for ­inotropic sup­port, ­were con­tin­u­ously reg­is­tered. ­Patients ­were ­divided ­into ­group A (uneventful ­course), ­group B (­ischemia by ECG, hemo­dy­namic ­stability) and ­group C (­ischemia by ECG and ­IABP).
­Results. ­After ­removal of X-­clamp an ­increase ­cTnI and CK-MB was ­observed in all ­patients. Five hrs ­after ­stop of CPB ­group A (8.3±4.2 µg/L) had ­lower ­cTnI ­values com­pared to ­group B (14.8±5.3 µg/L) (p=0.035) and C (54±22.8 µg/L) (p=0.023). The cut off ­value was 14.8 µg/L. Sen­si­tivity and spec­i­ficity (99%/97%) was ­higher for ­cTnI ­than for CK-MB (90%/30%). The pos­i­tive pre­dic­tive ­value of out­come was ­better for ­cTnI (86%) ­than for CK-MB (33%).
Con­clu­sion. ­CTnI is a spe­cific and sen­si­tive ­marker for eval­u­a­tion of per­i­op­er­a­tive myo­car­dial ­ischemia (PMI). Addi­tional deter­mi­na­tion of CK-MB ­activity ­does not pro­vide fur­ther clin­ical infor­ma­tion. ­CTnI ­should be the ­marker of ­first ­choice in ­CABG sur­gery.

top of page

Publication History

Cite this article as

Corresponding author e-mail