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CURRENT ISSUETHE JOURNAL OF CARDIOVASCULAR SURGERY

A Journal on Cardiac, Vascular and Thoracic Surgery


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The Journal of Cardiovascular Surgery 2002 December;43(6):799-802

CARDIAC SECTION 

 ORIGINAL ARTICLES

Plasma hepatocyte growth factor levels after open heart surgery for congenital heart disease

Komai H., Naito Y., Fujiwara K.

Department of Thoracic ­and Cardiovascular Surgery Wakayama Medical College, Wakayama, Japan

Background. Hepatocyte ­growth fac­tor (­HGF) is a poly­pep­tide ­which ­acts pro­tec­tive­ly ­against endo­the­lial ­cell dys­func­tion. A ­high plas­ma lev­el of ­HGF is ­shown ­when ­the endo­the­li­um is ­injured. We meas­ured plas­ma ­HGF lev­els dur­ing ­and ­after ­open ­heart oper­a­tions ­for con­gen­i­tal ­heart dis­ease, to elu­ci­date ­its involve­ment ­with endo­the­lial ­cell inju­ry.
Methods. Experimental ­design: pros­pec­tive ­study. Setting: per­i­op­er­a­tive set­ting. Patients: 18 chil­dren elec­tive­ly oper­at­ed ­upon ­for con­gen­i­tal ­heart dis­ease ­using ­CPB.
Results. Plasma ­HGF lev­els (ng/ml) ­before car­di­o­pul­mo­nary ­bypass (­CPB) ­were 0.36±0.07 in 10 chil­dren (S-­group) ­who ­were old­er ­and ­with sim­pler dis­eas­es, ­and 0.48±0.12 in 8 chil­dren (C-­group) ­who ­were young­er ­and ­with rel­a­tive­ly com­plex dis­eas­es. ­HGF lev­els sig­nif­i­cant­ly ­increased ­after ­CPB, ­and grad­u­al­ly ­decreased there­af­ter. Plasma ­HGF lev­els 3 ­and 6 ­hours ­after ­CPB ­were sig­nif­i­cant­ly great­er in ­the C-­group ­than in ­the S-­group (1.13±0.12 vs 1.68±0.1 6 3 ­hours ­after, ­and 1.09±0.19 vs 2.35±0,43 6 ­hours ­after; p<0.05 ­for ­both). There ­were sig­nif­i­cant pos­i­tive cor­re­la­tions ­between ­HGF lev­els 6 ­hours ­after ­CPB ­and ­the dura­tion of ­the ­CPB, ­the aor­tic cross­clamp­ing ­time, ­and plas­ma throm­bo­mod­u­lin lev­els ­just ­after ­CPB in ­all ­patients (p<0.05 ­for ­all).
Conclusions. This ­data sug­gests ­that ­increased ­HGF lev­els ­are asso­ciat­ed ­with endo­the­lial ­cell inju­ry ­induced by ­CPB, ­and ­that ­the increas­es ­are ­much great­er in young­er ­patients ­with com­plex anom­a­lies.

language: English


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