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The Journal of Cardiovascular Surgery 2002 October;43(5):693-6

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

α-tocopherol (Vitamin E) and Iloprost attenuate reperfusion injury in skeletal muscle ischemia/reperfusion injury

Bozkurt A. K.

Department of Cardiovascular Surgery University of Istanbul, Cerrahpas¸a Medical Faculty, Istanbul, Turkey


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Background. The ­aim of ­this ­study ­was to clar­i­fy ­the ­role of α-tocoph­e­rol (vita­min E) ­and ilo­prost on skel­e­tal mus­cle ische­mia/reper­fu­sion inju­ry.
Methods. Setting: ani­mal ­research labor­a­to­ry of a uni­ver­sity hos­pi­tal. Experimental ­design: ­the ­iliac arter­ies of ­the 24 ­adult Sprague-Dawley ­rats ­were ­clamped ­and 4 ­hours of ische­mia fol­lowed by 1 ­hour of reper­fu­sion ­was ­applied. In an ­attempt to ­decrease reper­fu­sion inju­ry, ­the ­rats ­were giv­en ­either α-tocoph­e­rol (n=8), ilo­prost (n=6) ­and 8 ­rats ­were giv­en nor­mal ­saline ­and ­served as con­trol ­group (n=8). Measures: ­blood pH, pO2, pCO2, ­HCO3, Na, K, crea­tine ­kinase (CPK), lac­tate dehy­drog­e­nase (­LDH) val­ues ­were deter­mined at ­the ­end of ­the reper­fu­sion peri­od. Malondialdehyde (­MDA), a prod­uct of lip­id per­ox­i­da­tion, ­was meas­ured in ­blood, mus­cle ­and ­lung as an indi­ca­tor of ­free rad­i­cals.
Results. Blood pO2 ­and ­HCO3 lev­els ­were sig­nif­i­cant­ly ­high (p<0.05); ­CPK, LDH ­and ­MDA lev­els ­were sig­nif­i­cant­ly ­low (p<0.05) in ­both α-tocoph­e­rol ­and ilo­prost ­groups ­when com­pared to ­the con­trol ­group. Similarly, ­the ­MDA lev­els in ­the gas­troc­ne­mi­us mus­cle ­were sig­nif­i­cant­ly ­low in ­both treat­ment ­groups ­when com­pared to ­the con­trols (p<0.05). There ­was no sig­nif­i­cant dif­fer­ence ­between ­groups in oth­er param­e­ters.
Conclusions. The ­results sug­gest ­that, ­both α-tocoph­e­rol ­and ilo­prost ­are use­ful ­for atten­u­at­ing oxi­da­tive mus­cle dam­age occur­ring ­after a peri­od of ische­mia/ reper­fu­sion.

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