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A Journal on Cardiac, Vascular and Thoracic Surgery

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The Journal of Cardiovascular Surgery 2002 October;43(5):589-94

language: English

Expression of basic fibroblast growth factor and its receptor-1 in cardiac myxoma

Fujisawa H. 1, Koide N. 1, Kono T. 1, Takayama K. 1, Tsukioka K. 1, Wada Y. 1, Zhang T. 1, Kitahara H. 1, Nakano H. 1, Suzuki J.-I. 2, Isobe M. 3, Amano J. 1

1 Second Depart­ment of Sur­gery and
2 First Depart­ment of ­Internal Med­i­cine, ­Shinshu Uni­ver­sity ­School of Med­i­cine, Mat­su­moto
3 Depart­ment of Car­di­o­vas­cular Med­i­cine, ­Tokyo Med­ical and ­Dental Uni­ver­sity, ­Tokyo, ­Japan


Back­ground. To ­clarify the sig­nif­i­cance of ­basic fibro­blast ­growth ­factor (­bFGF) in angio­gen­esis or pro­life­ra­tive ­activity in car­diac ­myxoma, the expres­sion of ­bFGF and its ­receptor (­FGFR-1) ­were immu­no­his­to­chem­i­cally exam­ined.
­Methods. For­malin-­embedded tis­sues of car­diac myx­omas ­were ­obtained by sur­gical resec­tion ­from 15 ­patients and ana­lyzed by immu­nos­taining of ­bFGF and ­FGFR-1. The micro­vessel den­sity was meas­ured in the 15 myx­omas ­using ­platelet ­derived endo­the­lial ­cell adhe­sion mole­cule-1. For eval­u­a­tion of pro­life­ra­tive ­activity of the car­diac myx­omas, pro­life­rating ­cell ­nuclear ­antigen (­PCNA) immu­nos­taining was per­formed, and the ­PCNA ­labeling ­index was meas­ured in ­each sec­tion.
­Results. ­bFGF and ­FGFR-1 ­were ­observed in 73.3% and 67.7% of the myx­omas, respec­tively. ­There was a ­close cor­re­la­tion ­between the expres­sion of ­bFGF and ­FGFR-1. ­This co-expres­sion was fre­quently ­observed in the ­myxoma ­cells ­around the micro­ves­sels ­appearing as a ­ring struc­ture. ­Regarding pos­sible rela­tion­ships ­between the expres­sion of ­bFGF or ­FGFR-1 and the cli­nic­o­path­o­logic fea­tures, ­there ­were no param­e­ters ­excluding the mac­ro­scopic ­type of ­myxoma. The micro­vessel den­sity in the myx­omas ­with ­bFGF or ­FGFR-1 expres­sion was ­higher ­than ­that in myx­omas ­without it. The ­PCNA ­labeling ­index in myx­omas ­with ­bFGF expres­sion was ­higher ­than ­that in myx­omas ­without it, and the ­PCNA ­labeling ­index ­tended to be ­higher in myx­omas ­with ­FGFR-1 expres­sion ­than ­that in myx­omas ­without it.
Con­clu­sions. ­bFGF and/or ­FGFR-1 was ­expressed in ­some of car­diac ­myxoma, and may be an impor­tant ­role for ­tumor angio­gen­esis and pro­life­ra­tive ­activity.

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