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THE JOURNAL OF CARDIOVASCULAR SURGERY

A Journal on Cardiac, Vascular and Thoracic Surgery


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The Journal of Cardiovascular Surgery 2002 June;43(3):301-6

language: English

Evaluation of kangaroo pericardium as an alternative substitute for reconstructive cardiac surgery

Neethling W. M. L., Cooper S. *, Van Den Heever J. J. **, Hough J. **, Hodge A. J.

From the Depart­ment of ­Cardio-Tho­racic Sur­gery Fre­mantle ­Heart Insti­tute Fre­mantle, ­Western Aus­tralia
*Depart­ments of ­Pathology and **­Cardio-Tho­racic Sur­gery Uni­ver­sity of the ­Free ­State, Bloem­fontein, ­South ­Africa


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Back­ground. Bio­pros­thetic mate­rials (­human, ­bovine and por­cine) are ­used in var­ious ­cardio-tho­racic ­repair and replace­ment pro­ce­dures ­because of excel­lent per­for­mance and low throm­bog­e­nicity. ­These bio­pros­thetic sub­sti­tutes ­fail due to degen­er­a­tion and cal­cifi­ca­tion. ­This ­study exam­ines the mor­phology, ten­sile prop­er­ties and cal­cifi­ca­tion poten­tial of kan­garoo per­i­car­dium in ­vitro and in ­vivo.
­Methods. ­Bovine (con­trol ­tissue) and kan­garoo per­i­car­dium, ­fixed in 0.625% buf­fered glu­ta­ral­de­hyde, ­were exam­ined by ­light and scan­ning elec­tron micros­copy. A stan­dard ­method was ­used for ­biaxial ­testing. Per­i­car­dial ­strips (10×5 mm) ­were ­implanted sub­cu­ta­ne­ously ­into ­male ­Wistar ­rats and ­retrieved ­after 4, 6 and 8 ­weeks and exam­ined by Von ­Kossa’s ­stain tech­nique and ­atomic absorp­tion spec­tro­pho­tom­etry.
­Results. His­tology ­revealed ­serosa and ­fibrosa ­cell ­layers in ­both tis­sues. Elec­tron micros­copy ­showed a ­densely ­arranged col­lagen ­matrix in kan­garoo per­i­car­dium. Kan­garoo per­i­car­dium cal­ci­fied sig­nif­i­cantly ­less ­than ­bovine per­i­car­dium at 4 ­weeks (0.80±0.28 ­versus 21.60±4.80 µg/mg) at 6 ­weeks (0.48±0.08 ­versus 32.80±14.4 µg/mg) and at 8 ­weeks (2.40±1.20 ­versus 30.40±17.20 µg/mg), respec­tively.
Con­clu­sions. Kan­garoo per­i­car­dium has a ­densely ­arranged col­lagen ­matrix ­with a ­higher exten­sibility and sig­nif­i­cantly ­lower cal­cifi­ca­tion poten­tial. There­fore, kan­garoo per­i­car­dium ­could be ­used as an alter­na­tive sub­sti­tute in car­diac sur­gery ­because of its low cal­cifi­ca­tion poten­tial.

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