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Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632
Online ISSN 1827-191X
Nishibe T. 1,2, O’Donnel S. 2, Pikoulis E. 2, Rich N. 2, Okuda Y. 3, Kumada T. 4, Kudo F. 1, Tanabe T. 1, Yasuda K. 1
1 Department of Cardiovascular Surgery Hokkaido University School of Medicine, Sapporo, Japan
2 Department of Surgery Uniformed Services University of the Health Sciences Bethesda, USA
3 Sumitomo Electric Industries, Co. Ltd., Osaka, Japan
4 Dai-ichi Pharmaceutical Company Ltd., Tokyo, Japan
Background. We developed a new fibronectin bonding to expanded polytetrafluoroethylene (ePTFE) and previously reported that, in a dog carotid implant model, fibronectin bonding improves graft healing in high porosity ePTFE grafts. The purpose of this study was to further investigate the effect of the fibronectin bonding on graft healing in a pig carotid implant model.
Methods. Fifteen pigs received a high porosity ePTFE graft treated with the fibronectin bonding (fibronectin-bonded graft) on one side and an untreated graft (non-bonded graft) on the contralateral side. The grafts were explanted at intervals of 3 and 6 weeks and subjected to histological studies.
Results. At 3 weeks, the neointima of fibronectin-bonded grafts was better organized than that of non-bonded grafts. At 6 weeks, the morphologic features of the neointima were the same in fibronectin-bonded and non-bonded grafts. The neointima was completely organized.
Conclusions. Together with the previous results with the dog model, fibronectin bonding could be expected to improve healing of the high porosity ePTFE grafts in humans.