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CURRENT ISSUETHE JOURNAL OF CARDIOVASCULAR SURGERY

A Journal on Cardiac, Vascular and Thoracic Surgery

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632

Frequency: Bi-Monthly

ISSN 0021-9509

Online ISSN 1827-191X

 

The Journal of Cardiovascular Surgery 2001 August;42(4):561-4

THORACIC SECTION 

    CASE REPORTS

Immunohistochemical study with antibody to glycoprotein GCDFP-15 for metastatic lung cancer from breast cancer

Nonami Y., Hisa S., Yamamoto A., Sasaguri S. *, Kiyoku H. **, Kurumaya H. ***

From the *Department of Surgery II
**Department of Pathology Kochi Medical School, Kohasu, Nankoku, Kochi
***Division of Pathology Ishikawa Municipal Hospital Kanazawa, Japan

Even ­when ­gross path­o­log­ic spec­i­mens are avail­able, eval­u­a­tion is ­always com­pli­cat­ed due to the dif­fi­cul­ty in dis­tin­guish­ing the path­o­log­ic diag­no­sis of an aden­o­car­cin­o­ma as a pul­mo­nary metas­ta­sis of the ­breast or ­lung. In ­this ­paper, we ­describe the use­ful­ness of a pre­op­er­a­tive immu­no­his­to­chem­i­cal ­study ­using ­gross cys­tic dis­ease ­fluid pro­tein-15 (­GCDFP-15). A 50-­year-old wom­an, who had under­gone a ­right rad­i­cal mas­tec­to­my due to an infil­trat­ing duc­tal car­ci­no­ma 4 ­years pre­vi­ous­ly, was admit­ted ­because of an abnor­mal shad­ow on ­chest roent­gen­o­gra­py.
A ­chest CT ­scan ­showed a nod­ule 20 mm in diam­e­ter ­with an irreg­u­lar mar­gin and vas­cu­lar involve­ment in the S3 ­region of the ­right ­lung. Though the spec­i­men ­from a per­cut­ane­ous CT guid­ed nee­dle biop­sy ­revealed char­ac­ter­is­tic path­o­log­ic find­ings of a pri­mary ­lung aden­o­car­cin­o­ma ­under H.E. ­stain, ­which was rec­om­mend­ed for ­lobar resec­tion, we re-exam­ined ­that spec­i­men immu­no­his­to­chem­i­cal­ly, ­which dis­closed ­that the ­tumor ­cells ­were neg­a­tive for the anti­body to pul­mo­nary sur­fac­tant apo­pro­tein and ­were pos­i­tive for ­GCDFP-15 anti­body.
Therefore, the diag­no­sis of a met­a­stat­ic ­breast car­ci­no­ma in the ­lung was estab­lished. Upon her ­request, a ­wedge resec­tion of the ­right ­upper ­lobe includ­ing the ­tumor was per­formed ­under vid­eo-assist­ed tho­rac­os­cop­ic sur­gery (­VATS). Her post­op­er­a­tive ­course was unevent­ful.

language: English


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