Advanced Search

Home > Journals > The Journal of Cardiovascular Surgery > Past Issues > The Journal of Cardiovascular Surgery 2001 April;42(2) > The Journal of Cardiovascular Surgery 2001 April;42(2):187-92

ISSUES AND ARTICLES   MOST READ   eTOC

CURRENT ISSUETHE JOURNAL OF CARDIOVASCULAR SURGERY

A Journal on Cardiac, Vascular and Thoracic Surgery

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632

Frequency: Bi-Monthly

ISSN 0021-9509

Online ISSN 1827-191X

 

The Journal of Cardiovascular Surgery 2001 April;42(2):187-92

CARDIAC PAPERS 

    ORIGINAL ARTICLES

The effect of Celsior solution on 12-hour cardiac preservation in comparison with University of Wisconsin solution

Mohara J., Takahashi T., Oshima K., Aiba M., Yamagishi T., Takeyoshi I., Matsumoto K. *, Morishita Y.

From the ­Second Depart­ment of Sur­gery Gunma Uni­ver­sity ­School of Med­i­cine, Gunma
*Depart­ment of ­Pathology Nippon Med­ical ­School ­Second Hos­pital Kanagawa, Japan

Back­ground. Cel­sior is a new extra­cel­lular-­type pres­er­va­tion solu­tion ­which has ­been devel­oped to act not ­only as a ­storage ­medium but ­also as a per­fu­sion ­fluid ­during ­initial ­donor ­heart ­arrest, post­storage ­graft reim­plan­ta­tion and ­early reper­fu­sion. We ­designed ­this experi­mental ­study to eval­uate the ­effect of the Cel­sior solu­tion in com­par­ison ­with the Uni­ver­sity of Wis­consin solu­tion ­from the view­point of ­energy deple­tion.
­Methods. ­Adult mon­grel ­dogs ­weighing 9 to 13 kg ­were ­divided ­into two ­groups. In the UW ­group (n=7), a 4°C Uni­ver­sity of Wis­consin solu­tion was ­used for cor­o­nary vas­cular ­washout and ­storage fol­lowing car­diac ­arrest ­using a glu­cose-­insulin-potas­sium solu­tion. In the Cel­sior ­group (n=7), the Cel­sior solu­tion was ­used to ­obtain car­diac ­arrest, cor­o­nary vas­cular ­washout and ­storage. ­High ­energy phos­phate ­levels and myo­car­dial pH ­were meas­ured ­using 31P-­nuclear mag­netic res­o­nance spec­tros­copy imme­di­ately ­after pres­er­va­tion and at 3, 6 and 12 ­hours ­after pres­er­va­tion. ­After 12-­hour ­cold ­storage, ­left ven­tric­ular ­free ­wall tis­sues ­were har­vested for his­to­log­ical exam­ina­tion.
­Results. ­High ­energy phos­phate ­levels and myo­car­dial pH ­were sig­nif­i­cantly ­better pre­served in the Cel­sior ­group ­than in the UW ­group. In the his­to­log­ical find­ings, gly­cogen gran­ules ­were pre­served ­well in the Cel­sior ­group.
Con­clu­sions. We con­clude ­from our ­study ­that the Cel­sior solu­tion is com­par­able to the Uni­ver­sity of Wis­consin solu­tion for use in 12-­hour ­heart pres­er­va­tion in ­canine ­models.

language: English


FULL TEXT  REPRINTS

top of page