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THE JOURNAL OF CARDIOVASCULAR SURGERY
A Journal on Cardiac, Vascular and Thoracic Surgery
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632
CASE REPORTS THORACIC PAPERS
The Journal of Cardiovascular Surgery 2000 October;41(5):773-6
Long-term survival of patients treated with octreotide for metastatic well differentiated neuroendocrine carcinoma of the lung
Filosso P. L., Croce S. *, Oliaro A., Ruffini E.
From the Department of Thoracic Surgery *Department of Biomedical Sciences and Human Oncology University of Turin, Turin, Italy
Two patients with a radically operated well differentiated neuroendocrine carcinoma (WDNC) of the lung who developed a carcinoid syndrome due to metastatic spread of the tumor are reported. Treatment with somatostatin analogue octreotide was administered to both patients following their refusal of a standard chemotherapic regimen. Prompt resolution of the carcinoid syndrome was observed in both following octreotide treatment and both patients are alive and well after more than four years without evidence of further progression of the tumor. It is suggested that octreotide should be considered as an effective therapy in WDNC for the control of the disease and associated paraneoplastic syndromes.