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The Journal of Cardiovascular Surgery 2000 August;41(4):541-5

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Myocardial fixation of anticardiac troponin I antibody and cardiac troponin I release

Alwan K., Chocron S., Mourand J. L., Toubin G. 1, Gauchez P. 2, Kantelip B. 2, Kantelip J. P. 1, Etievent J. P.

From the Department of Thoracic and Cardiovascular Surgery 1 Department of Pharmacology 2 Department of Pathology Saint-Jacques Hospital, Besançon, France


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Background. The three­fold aim of ­this experi­men­tal ­study was to ­test the cor­re­la­tion of car­diac tro­po­nin I ­released to myo­car­dial infarc­tion ­size and myo­car­dial fix­a­tion of anti­car­diac tro­po­nin I anti­body and to deter­mine how ­long ­after myo­car­dial infarc­tion the meas­ure of car­diac tro­po­nin I con­cen­tra­tion can eval­u­ate myo­car­dial infarc­tion ­size.
Methods. Forty rab­bits ­were ­assigned ­either to a con­trol ­group or to an experi­men­tal pre­con­di­tioned ­group. Infarction was ­obtained by tight­en­ing a ­snare ­around the ­left ante­ri­or descend­ing ­artery. Serial ­venous ­blood sam­ples ­were ­drawn for meas­ure­ment of car­diac tro­po­nin I. The rab­bits ­were sac­ri­ficed at 72 ­hours and a his­to­log­i­cal ­study was per­formed to deter­mine the ­infarct ­size and the ­size of the ­area ­void of fix­a­tion of anti­car­diac tro­po­nin I anti­body.
Results. There was a lin­e­ar cor­re­la­tion ­between the ­total ­amount of CTn I ­released and ­both ­infarct ­size (r=0.45, p<0.02) and the ­size of the ­area ­void of ­anti-car­diac tro­po­nin I anti­body (r=0.47, p<0.02). These two siz­es ­were strong­ly cor­re­lat­ed (r=0.95, p<0.02). The ­hour 9 CTn I sam­ple was the ­best cor­re­lat­ed ­with ­both the ­infarct ­size (r=0.47, p<0.02) and the ­size of ­area ­void of anti­car­diac tro­po­nin I anti­body (r=0.45, p<0.02).
Conclusions. Our ­study ­shows ­that: 1) car­diac tro­po­nin I ­release is cor­re­lat­ed to ­both myo­car­dial infarc­tion ­size and the ­size of ­area ­void of fix­a­tion of anti­car­diac tro­po­nin I anti­body, 2) the ­area ­void of anti­car­diac tro­po­nin I anti­body fix­a­tion ­includes the ­whole ischem­ic ­area, and 3) eval­u­a­tion of myo­car­dial infarc­tion ­size can be ­obtained by CTn I con­cen­tra­tion as ear­ly as the ­ninth ­hour.

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