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THE JOURNAL OF CARDIOVASCULAR SURGERY

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The Journal of Cardiovascular Surgery 2000 June;41(3):459-62

language: English

Rupture of pseudointima in an implanted vascular prosthesis: immunohistological study of plasminogen activators and matrix metalloproteinases

Urayama H., Katada S., Kasashima F., Tanaka Y., Kawasuji M., Watanabe Y.

From The First Department of Surgery Kanazawa University School of Medicine Kanazawa, Japan


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We inves­ti­gat­ed ­late-­onset anas­to­mot­ic sten­o­sis in an implant­ed pros­thet­ic ­graft. Rupture of the pseu­do­in­ti­ma and hem­or­rhag­ing ­from the ­vasa vas­or­um ­were ­observed at the bor­der of the col­lag­e­nous tis­sue and ­fibrin ­layer. An immu­no­his­to­log­i­cal ­study ­showed ­that the ­fibrin ­layer was pos­i­tive for tPA, but weak­ly pos­i­tive for PAI-1. Some neu­troph­ils and mono­cyte/mac­ro­phag­es in the ­fibrin ­layer ­were immu­nos­tained for tPA, uPA, uPAR, and MMP-1, -2 and -3. Some spin­dle-­shaped ­cells sur­round­ing the ­graft ­were immu­nos­tained for uPA, uPAR, MMP-1, -2, -3, -7 and -9, and ­TIMP-1 and -2. The endo­the­lial ­cells of ­some micro­ves­sels ­were pos­i­tive for MMP-1 and -2, and tPA. Some mul­ti-nucle­at­ed ­giant ­cells ­were immu­nos­tained for MMP-7 and-9, tPA, PAI-1, uPA, and uPAR. Overexpressed MMPs and PAs pos­sibly ­caused instabil­ity of the pseu­do­in­ti­ma.

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