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CURRENT ISSUETHE JOURNAL OF CARDIOVASCULAR SURGERY

A Journal on Cardiac, Vascular and Thoracic Surgery

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632

Frequency: Bi-Monthly

ISSN 0021-9509

Online ISSN 1827-191X

 

The Journal of Cardiovascular Surgery 1999 August;40(4):495-9

CARDIAC PAPERS 

    ORIGINAL ARTICLES

ATP-­MgCl2 util­iza­tion for ­spinal ­cord pro­tec­tion during experi­mental tho­racic ­aortic occlu­sion

Ulus A. T., Saritas Z., Yamak B., Surucu S.*, Tuncer M.*, Katircioglu S. F.

From the ­Türkiye ­Yüksek ­Ihtisas Hos­pital, Car­di­o­vas­cular Sur­gery ­Clinic * Hacet­tepe Uni­ver­sity, ­Faculty of Med­i­cine Depart­ment of ­Anatomy, ­Ankara, ­Turkey

Back­ground. In ­this experi­mental ­study we inves­ti­gate the ­effect of intra­ve­nous ATP-­MgCl**2 admin­is­tra­tion for pre­ven­tion of ­spinal ­cord ­injury occur­ring due to ­ischemia ­induced by ­aortic ­cross ­clamping.
­Methods. Ten rab­bits ­were ­studied. The abdom­inal ­aorta is ­ligated ­below the ­left ­renal ­artery. ­Five rab­bits ­served as a con­trol ­group and ­received no med­i­ca­tion ­during 30 min­utes of ­ischemic ­period. The ­other 5 rab­bits ­received ­during 30 min­utes of ­aortic occlu­sion ATP-­MgCl2 solu­tion (100 µmol/ml for ­each). ­Distal and prox­imal ­aortic pres­sures are meas­ured ­during the pro­ce­dure and inci­sions are ­closed. Rab­bits are ­observed for 24 ­hours for ­their neu­ro­log­ical ­status and ­scored accord­ingly. Spec­i­mens ­from the ­spinal ­cord are ­taken for elec­tron micro­scopic inves­ti­ga­tions.
­Results. All of the con­trol ­group rab­bits ­were para­plegic. One of the ATP-­MgCl2 ­group rab­bits was par­a­pa­resic and the ­others ­were ­normal. ­Distal ­aortic pres­sure was 9±3 ­mmHg for the con­trol ­group and was 17±4 ­mmHg for the ATP-­MgCl2 ­group (p<0.05). Elec­tron micro­scopic ­studies ­showed the pre­served ultra­struc­ture for ATP-­MgCl2 ­group.
Con­clu­sions. ATP-­MgCl2 admin­is­tra­tion ­during ­spinal ­cord ­ischemia ­reduces ­spinal ­cord ­injury. ­This may be an alter­na­tive ­modality for the pro­tec­tion of the ­spinal ­cord ­during ­aortic sur­gery.

language: English


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