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A Journal on Cardiac, Vascular and Thoracic Surgery

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The Journal of Cardiovascular Surgery 1999 June;40(3):355-61

language: English

Effects of coen­zyme Q10 on myo­car­dial pro­tec­tion during car­diac ­valve replace­ment and scav­enging free rad­ical ­activity in ­vitro

Zhou M., Zhi Q., TAng Y., Yu D. *, Han J. *

From the Depart­ment of Car­di­o­vas­cular Sur­gery China-­Japan Frien­dship Hos­pital, ­Beijing
* Department of Bio­physics, ­China-­Japan Friend­ship Insti­tute of Clin­ical Med­ical Sci­ences, ­Beijing, ­China


Back­ground. To eval­uate the ­effects of CoQ10 on myo­car­dial pro­tec­tion in ­patients under­going car­diac ­valve replace­ment and ­direct scav­enging ­free rad­i­cals ­activity in ­vitro.
­Methods. Twen­ty-­four ­patients ­were ran­domly ­divided ­into two ­groups. ­Twelve ­patients in the CoQ10 ­group ­received intra­ve­nous and intra­cor­o­nary CoQ10-­treated “­round the oper­a­tive ­period”. ­Twelve ­patients in the con­trol ­group ­received no CoQ10-treat­ment.
Meas­ures. ­Plasma mal­on­di­al­de­hyde (MDA) con­cen­tra­tion, eryth­ro­cyte super­oxide dis­mu­tase (SOD) ­activity, and ­serum car­diac iso­en­zyme of crea­tine ­kinase (CK-MB) ­were meas­ured in the per­i­op­er­a­tive and post­op­er­a­tive ­period. The ­effects of CoQ10 ­direct scav­enging ­free rad­i­cals ­were deter­mined ­with elec­tron ­spin res­o­nance (ESR) and ­spin-trap­ping tech­niques by an in ­vitro ­study.
­Results. ­Plasma MDA con­cen­tra­tion and ­serum CK-MB ­levels in the CoQ10 ­group ­were sig­nif­i­cantly ­lower ­than ­those in the con­trol ­group. Eryth­ro­cyte SOD ­activity in the CoQ10 ­group was sig­nif­i­cantly ­higher ­than ­that in the con­trol ­group. CoQ10 ­showed an ­obvious ­hydroxyl rad­ical scav­enging ­activity, but it ­could not scav­enge super­oxide ­anion rad­i­cals.
Con­clu­sions. ­These find­ings dem­on­strated ­that the use of intra­ve­nous and intra­cor­o­nary CoQ10-treat­ment may ­play a ­more ben­e­fi­cial pro­tec­tive ­role ­during car­diac ­valve replace­ment ­through its anti­ox­i­dant prop­er­ties and mem­brane sta­bil­iza­tion, as ­well as ­through its ­ability to scav­enge ­hydroxyl rad­i­cals ­directly.

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