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THE JOURNAL OF CARDIOVASCULAR SURGERY

A Journal on Cardiac, Vascular and Thoracic Surgery


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The Journal of Cardiovascular Surgery 1999 April;40(2):279-80

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: English

Repair of abdominal aortic aneurysm in severe Factor VII deficiency

Ferlan G., De Pasquale C., Testini M., Agnino A., D’Agostino D.

From the Division of Cardiac Surgery Faculty of Medicine University of Bari, Bari, Italy


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Con­gen­ital ­Factor VII defi­ciency is a ­rare dis­order asso­ciated ­with ­reduced ­levels of ­Factor VII ­activity. Replace­ment ­therapy is nec­es­sary to con­trol hem­or­rhaging or if sur­gery is ­needed. We ­report oper­a­tive treat­ment of one ­case of ­chronic abdom­inal ­aortic aneu­rysm in a ­patient ­affected by a ­severe ­form of con­gen­ital ­Factor VII defi­ciency (endog­e­nous ­FVII ­level <1%). The oper­a­tion was car­ried out ­after the admin­is­tra­tion of ­Factor VII con­cen­trate ­raised the ­Factor VII con­cen­tra­tion to hemo­static ­levels. The ­patient con­tinued to ­receive the con­cen­trate ­every 6 hrs ­during the ­first ­three post­op­er­a­tive ­days. ­Dosage was ­assessed to ­obtain ­Factor VII ­levels not ­lower ­than 25%. No post­op­er­a­tive ­bleeding or throm­botic ­events ­were ­observed. The ­patient was dis­charged in excel­lent con­di­tion.

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