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CURRENT ISSUETHE JOURNAL OF CARDIOVASCULAR SURGERY

A Journal on Cardiac, Vascular and Thoracic Surgery

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632

Frequency: Bi-Monthly

ISSN 0021-9509

Online ISSN 1827-191X

 

The Journal of Cardiovascular Surgery 1998 December;39(6):717-20

VASCULAR PAPERS 

    ORIGINAL ARTICLES

Residual inflam­ma­tory pro­cess after aor­toi­liac recon­struc­tive sur­gery

Perier C., Favre J. P.*, Granouillet R., Charmoin S.**, Barral X.*, Rousset H.**, Frey J.*

From the Depart­ment of Bio­chem­istry, the *Depart­ment of Car­diac and Vas­cular Sur­gery and the **Depart­ment of ­Internal Medicine Uni­ver­si­tary Hos­pital, ­Hôpital ­Nord
42055 ­Saint-­Etienne ­Cedex 2, ­France

Back­ground. The aim of the ­present ­study was to inves­ti­gate the inflam­ma­tory reac­tion and its evo­lu­tion in ­patients who under­went a pros­thetic vas­cular pro­ce­dure. More­over the par­tic­i­pa­tion of ­this ­chronic pro­cess, ­during the ­follow-up, as a pro­moting or a con­se­quence of vas­cular ­injury ­must be dis­cussed.
­Methods. ­Thirty-­four ­patients ­were ­enrolled in the ­study. All ­patients had an ­aortic dis­ease and under­went a pros­thetic vas­cular pro­ce­dure. Pre­op­er­a­tive exclu­sion cri­teria ­were an emer­gency sit­u­a­tion, dia­betes, infec­tion, ­chronic inflam­ma­tory dis­ease, ­cancer and hemop­athy. Post­op­er­a­tive exclu­sion cri­teria ­were the ­same ­together ­with abdom­inal com­pli­ca­tions and addi­tional sur­gery ­during the ­follow-up. The inflam­ma­tory pro­cess was inves­ti­gated ­with the meas­ure­ment of ­blood ­acute ­phase pro­teins, hap­tog­lobin, α1-gly­co­pro­tein ­acid, C-reac­tive pro­tein and inter­leukin-6, ­before, imme­di­ately ­after sur­gery and sev­eral ­months ­after sur­gery.
­Results. An ­increase in ­acute ­phase pro­teins was not ­observed to the ­same ­extent for all the ­studied ­patients. ­Before the sur­gical pro­ce­dure, ­chronic inflam­ma­tory pro­cess was ­revealed by an ­increase in hap­tog­lobin (52.9 p 100) and α1 gly­co­pro­tein ­acid (52.9 p 100) ­whereas ­increase in C-reac­tive pro­tein (26.4 p 100) and inter­leukin-6 (92 p 100) are ­related to an ­acute pro­cess. ­Later ­after sur­gery, the ­chronic inflam­ma­tory pro­cess ­remained but dif­fered ­from the ­observed pro­cess ­before sur­gery ­only by hap­tog­lobin (61.7 p 100) and inter­leukin-6 (47 p 100).
Con­clu­sions. The pre­sented ­results, ­observed ­during the ­follow-up of vas­cular sur­gery ­focused on per­sis­tent inflam­ma­tory pro­cess and the sur­gical pro­ce­dure did not ­modify the ­time ­course of ­this pro­cess. The evo­lu­tionary dis­ease ­could be con­sid­ered as ­chronic and inde­pen­dent of the ­local ­effect.

language: English


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