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THE JOURNAL OF CARDIOVASCULAR SURGERY
A Journal on Cardiac, Vascular and Thoracic Surgery
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632
ORIGINAL ARTICLES VASCULAR PAPERS
The Journal of Cardiovascular Surgery 1998 October;39(5):551-5
Thrombolysis with i.v. recombinant human tissue-type plasminogen activator in patients with bypass graft occlusion: a good adjunctive therapeutic mode (preliminary and case reports)
Agresta F., Michelet I., Boni V., Tonietto G.
From the Department of Surgery Ospedale Civile, Vittorio Veneto, Treviso, Italy
Background and methods. The authors report their experience with thrombolytic therapy in seven cases of graft thrombosis managed successfully with low-dose I.V. rt-TPA. In six patients the cause was an anatomical one and so, after the successful lysis, there was enough time to confirm a correct diagnosis and plan the “right” and “less extensive” surgical procedure, obviating it in one case with a “functional” cause of thrombosis.
Results. No complication directly attributable to rt-TPA infusion occurred, and no systemic fibrinogenolysis was registered in any cases. Judging from this experience, I.V. rt-TPA appears safe and effective in patients with graft thrombosis, proving to be a good adjunctive therapeutic mode.
Conclusions. Further studies are needed do delineate more clearly safe indication and the validity of this method.