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THE JOURNAL OF CARDIOVASCULAR SURGERY
A Journal on Cardiac, Vascular and Thoracic Surgery
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632
ORIGINAL ARTICLES CARDIAC PAPERS
The Journal of Cardiovascular Surgery 1998 April;39(2):181-91
The effect of cardiopulmonary bypass on blood cell filterability in children undergoing cardiac surgery
Bergman P., Belboul A., Friberg L. G., Mellgren G., Roberts D.
From the Department of Thoracic and Cardiovascular Surgery, Sahlgrenska Hospital and Department of Pediatric Surgery, Östra Hospital, University of Gothenburg, Sweden
Background. The extended use of cardiopulmonary bypass (CPB) in cardiac surgery is limited because of damage to blood which in adults has been assessed by alterations in blood cell rheology. Blood trauma assessment in children is difficult because of the restrictions in sample volume and frequency but needs to be established from time to time in order to study the tolerance to new surgical and extracorporeal techniques.
Materials and methods. Fourteen pediatric patients undergoing cardiac surgery with CPB for congenital heart disease corrections were studied. Whole blood, red blood cell and white blood cell rheology (filterability) were monitored before, during and after CPB using the St. George filtrometer that used small amounts of blood.
Results. The results showed that all the rheologic parameters were altered during the blood trauma of CPB and were outside the reference values before, during and after CPB.
Conclusions. This suggested that blood cell rheologic disturbances did not recover soon after CPB and this may be of interest in long term follow-up to understand responses and recovery patterns to disease and interventions associated with pediatric heart surgery using CPB.