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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers


Official Journal of the Italian Association for Cutaneous Ulcers
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Acta Vulnologica 2015 March;13(1):37-41

language: English, Italian

Treatment of perforating sore with autologous platelet gel: a case report

Caiazza M. 1, De Cenzo O. 1, Masini E. 1, Mininni V. 1, Maresca L. 2, Zuccarelli B. 1

1 Unit of Transfusion Medicine, Dei Colli di Napoli (Monaldi‑CTO‑Cotugno) Hospital, Naples, Italy;
2 Department of Angiology, Dei Colli di Napoli (Monaldi‑CTO‑Cotugno) Hospital, Naples, Italy


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The term “perforating sore” refers to a perforating ulcer process, approximately 2-3 cm in dimension, with reduced capacity for spontaneous healing, localised on the plantar surface of the foot. The most frequent causes are vascular disease of the lower limbs, obstructive arterial disease, but above all diabetes mellitus. The present paper looks at a very interesting case. A 73-year-old female patient diagnosed by the Angiology DH of the Dei Colli (Monaldi-CTO-Cotugno) Hospital, for perforating sore of the right foot sole, in the metatarsal region of the toes and a 2 x 2.5 cm lesion was brought to our attention. The Angiology Unit consulted the Department of Transfusion Medicine regarding possible treatment with autologous platelet gel. For treatment with autologous platelet gel the Vivostat® System was used. A total of 120 mL whole blood was drawn from a suitable patient and collected in the Vivostat® Prep Unit, from which subsequently about 6 mL of PRF were collected. Two weeks after the application of PRF, after complete removal of the dressing, almost complete healing was observed together with a complete regeneration of the tissue eroded by the ulceration and a fully revascularised bed. It was therefore decided not to proceed to other PRF applications.

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