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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers


Official Journal of the Italian Association for Cutaneous Ulcers
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Acta Vulnologica 2011 December;9(4):189-98

language: English, Italian

Vascular non-healing skin ulcers: efficacy of local treatment with hyaluronic acid benzilic esther, a mixture of aminoacids (glycine, L-lysine, L-leucine) and sodium hyaluronate. Personal experience

Palombi M., Martinelli F., Palombi L.

Unit of Vascular Surgery, C.T.O. A. Alesini Hospital, Rome, Italy


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The vascular-non-healing skin ulcers are skin lesions present for at least three-four weeks that, following an initial positive phase of treatment with conventional or advanced dressing, suddenly become “non-responders”. Their etiology is various and should be detected to obtain healing. Sometimes this is not enough and the healing process can suddenly stop. In an attempt to give a new input to the recovery of the healing process we wanted to test the efficacy of dressings with hyaluronic acid benzilic esther with a mixture of sodium hyaluronate and some aminoacids (glycine, L-lysine, L-leucine) on patients with vascular non-healing ulcers. We report a clinical series drawn from a series occurred from October 2009 to December 2010. The first case was a post-traumatic necrotizing ulcer infection; the second case and the third case were postphlebitic chronic venous ulcers. All non-healing ulcers, treated with hyaluronic acid benzilic esther and a combination of aminoacids (glycine, L-lysine, L-leucine) and sodium hyaluronate have responded with a “starter” effect on the resumption of the stopped healing process. This clinical series confirms that dressings with hyaluronic acid have a high starter power on non-healing vascular ulcers and that the local use of a hyaluronic acid scaffold with a mixture of aminoacids and sodium hyaluronate may further accelerate the healing process.

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