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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers
Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Acta Vulnologica 2010 September;8(3):135-9
Outpatient management of “hard-to-heal” chronic ulcers with vacuum-assisted-closure therapy
Rivolta N. 1, Buscarini E. 1, Maida S. 1, Riva F. 1, Piffaretti G. 1, Tozzi M. 1, Annoni M. 3, Mariscalco G. 2, Castelli P. 1
1 Vascular Surgery, Department of Surgical Sciences, Varese University Hospital, University of Insubria, Varese, Italy;
2 Cardiac Surgery, Department of Surgical Sciences, Varese University Hospital, University of Insubria, Varese, Italy;
3 General Surgery 1, Department of Surgical Sciences, Varese University Hospital, University of Insubria, Varese, Italy
Aim. The aim of this study was to compare the results of vacuum-assisted-closure therapy versus conventional foam dressing treatment on “hard-to-heal” ulcers.
Methods. The study enrolled 56 patients who presented at the hospital between January 2007 and September 2008. Conventionally treated group (group A) included the first 42 ulcers; 20 ulcers (32.2%) were treated with vacuum-assisted-closure therapy (group B).
Results. Primary end-point was 100% in group A, and 85% in group B. Mean healing time was 151 ± 22 days in group A vs.117 ± 12 days in group B (P=0.005). At one-year follow-up visit, 24 (57.1%) ulcers reappeared in group A and 5 (29.4%) in group B (P=0.05); freedom from recurrence was two months in group A vs. four months in group B.
Conclusion. Vacuum-assisted-closure therapy obtained similar overall healing rate of conventional medications but in shorter time. In addition, freedom from recurrence was longer than standard treatment.