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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers

Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index




Acta Vulnologica 2010 March;8(1):15-19

language: Italian

Role of hyaluronic acid in chronic non-responder skin lesions

Nebbioso G., Petrella F., Caprarella E.

Azienda Sanitaria Napoli-1 Centro, Napoli, Italia


The process of tissue repair is a very complex dynamic event. Systemic and local factors may affect tissue repair and stop the healing processes. In these lesions the use of materials such as esters of hyaluronic acid as a starting therapy and/or collagen applied in situ could lead to overcome the block in order to support the process of formation of extracellular matrix and collagen synthesis by fibroblasts, accelerating the healing. Fourteen patients with chronic ulcers of different etiology and of difficult resolution were selected. The use of advanced dressings indicated problems in the tissue repair process. The application of a dressing consisting of esters of hyaluronic acid (Hyalofill-F) on the bottom of the lesion, determines both the formation of a well-vascularized granulation tissue and of marked macroscopic proliferation margins.

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