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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers

Official Journal of the Italian Association for Cutaneous Ulcers
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Acta Vulnologica 2009 December;7(4):207-15

language: Italian

Practice-oriented recommendation for the treatment of critical colonised and local infected wounds using polihexanide

Dissemond J. 1, Gerber V. 2, Kramer A. 3, Riepe G. 4, Strohal R. 5, Vasel-BiergansA. 6, Eberlein T. 7

1 Clinica Universitaria di Essen, Clinica di Dermatologia, Venerologia e Allergologia, Essen, Germania
2 Formazione e Consulenza nel Trattamento delle Ferite Spelle, Germania
3 Istituto di Igiene e Medicina Ambientale dell’Università Ernst Moritz Arndt di Greifswald Greifswald, Germania
4 Stiftungsklinikum Mittelrhein, Centro di Medicina Vascolare e Trattamento Ferite, Boppard, Germania
5 Ospedale Universitario Zonale di Feldkirch, Reparto di Dermatologia e Venerologia, Feldkirch, Germania
6 Farmacia centrale Clinica di Stoccarda Katharinenhospital Diakonie-Klinikum Stuttgart Clinica Medica I, Stoccarda, Germania
7 Specialista in Dermatologia/, Venerologia - Allergologia, Norimberga, Germania


Wound infections are special and challenging situations in therapy of acute and chronic wounds. Typical complications are riskful not only for therapeutic process but also for amputation and viability of patients. Polihexanide is an exceedingly appropriate antimicrobial substance for using in critical colonised and local infected acute and chronic wounds. This evaluation is based on different properties of the compound like the broad antimicrobial spectrum, the excellent cell and tissue tolerability, the binding capacity to organic matrix, low risk of contact sensitization and adjuvant effects to wound healing. Up to now there are no microbial resistances observed.

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