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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers

Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index




Acta Vulnologica 2009 September;7(3):101-2:137-44

language: Italian

Ozone efficacy assessment in chronic venous skin lesion repair

Petrella F. 1, Nebbioso G. 2

1 ASL Napoli 1 Centro, Portici, Italia
2 ASL Napoli 1 Centro, Napoli, Italia


The ozone is a natural component in the atmosphere. It is an unstable gas used in industries and in medical fields. In the industries, it is mostly used for its disinfectant and sanitising properties. Recently, we have seen promising results after research regarding the application of this substance on live tissue has confirmed that ozone stimulates the natural defence of cells and increases their energy levels. The ozone interacts with three fundamental metabolic lines (protein, fat and carbohydrate metabolism) and increases the deformability of erythrocytes, thus increasing the oxygenation level of the tissue. We have evaluated the clinical application of a substance derived from ozone deterioration (ozonolysis), called an "ozonide". The stabilisation of this substance is made possible by applying very sophisticated technology which produces oils. In these oils, the double bonds have been saturated by three atoms of ozone oxygen, making the compound stable and usable for cosmetological purposes. Its clinical use in treating dermo-epidermic lesions in venous skin ulcers has been evaluated by testing a control group at pre-determined times. The results of this experiment show that this substance plays a positive role in the process of repairing chronic skin lesions.

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