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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers
Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Acta Vulnologica 2009 June;7(2):71-3
Comparison of the binding capacity of collagen from different origin for IL-1b and TNF-a
Wiegand C., Abel M., Ruth P., Hipler U.-C.
1 Clinica di Dermatologia e Allergologia Dermatologica Università Friedrich Schiller, Jena, Germania
2 Lohmann & Rauscher GmbH & Co. KG Rengsdorf, Germania
Chronic wounds contain elevated levels of inflammatory cytokines like IL-1b and TNF-a. This overproduction leads to severe tissue damage and impairs wound-healing. Hence, the reduction of these mediators is a suitable way to promote normal healing. As collagen is known to be able to bind significant amounts of cytokines a wide variety of wound dressings containing collagen of different type and origin are used clinically. Within the present study we investigated the influence of the collagen origin (bovine, porcine and equine) on the binding capacity for IL-1b and TNF-a in vitro. It could be confirmed that collagen possesses a high binding capacity for different inflammatory cytokines. Consequently, collagen containing dressings should be able to improve the healing outcome of chronic wounds by decreasing these excessive mediator concentrations. Nonetheless, the choice of the collagen origin does influence the wound dressing performance. Bovine collagen was found to perform best in the binding assays.